Scientists uncover the cause of early brain aging

Researchers from Fujita Health University and the Tokyo Institute of Medical Science have identified a new biomarker that may indicate accelerated brain aging and be associated with various anxiety disorders, according to *Neuropsychopharmacology*.

During the study, specialists analyzed the genetic profiles of 17 mouse models suffering from different neurological and mental disorders. They observed a condition known as “hippocampal hypermaturity.” The hippocampus—a region of the brain responsible for emotions and memory—undergoes abnormally rapid development and aging in this state, leading to increased anxiety levels and impaired emotional regulation.

According to lead researcher Hideo Hagihara, accelerated hippocampal maturation may represent a shared molecular basis for mental conditions such as anxiety, depression, and schizophrenia. Scientists hope this finding could eventually serve as a new diagnostic tool and provide a foundation for developing methods to prevent and treat mental illnesses associated with early brain aging.

Other studies suggest that regular physical activity—such as aerobic exercise—can slow the aging process of the brain and improve cognitive functions. Maintaining an active social life and engaging in mentally stimulating activities, such as solving puzzles or learning new languages, also helps preserve brain health.

If these findings are confirmed, they could open new opportunities for treating mental disorders and improving the quality of life for those affected. The use of new biomarkers to assess brain condition and aging processes could play a crucial role in early diagnosis and prevention of such diseases.

Earlier, researchers from the Federal University of Rio Grande do Sul in Brazil discovered that extract from American basil can slow brain aging while reducing oxidative stress and inflammation.

                                      Mohichehra Qadamova