New method for restoring the heart after a heart attack discovered

Scientists at the Lewis Katz School of Medicine have discovered a new method to restore heart tissue after a heart attack. The findings were published in the journal "Theranostics".

According to the study, researchers identified that activating the PSAT1 gene stimulates the regeneration of heart tissue. While the PSAT1 gene is active during fetal development, it becomes largely dormant in adults. To reawaken its function, scientists created a modified messenger RNA (modRNA) containing the PSAT1 gene and injected it into the heart tissue of mice immediately after a heart attack. The treatment led to the division of heart muscle cells, reduced scarring, and the formation of new blood vessels — significantly improving heart function in the animals.

Researchers explained that PSAT1 boosts the synthesis of the amino acid serine, which plays a vital role in protecting cells from stress and repairing DNA. The key player in this regeneration process is the protein YAP1, which is essential for the effect of PSAT1. In the absence of YAP1, the regeneration process does not occur.

The technology used — modRNA — has previously been applied in the development of mRNA vaccines against COVID-19. Scientists emphasized that this method delivers genetic material to cells without altering DNA, thereby minimizing risks.

Experts believe that this approach could pave the way for new treatments for heart failure. Rather than simply supporting the heart, this method offers the potential for true regeneration.

As a reminder, a previously unknown blood group antigen was recently discovered in a woman from the Kolar district of Karnataka, India.